Mahdi Shahriari; Maryam Namavari; Mazyar Ziyaeyan; Peyman Etemadfar
Volume 24, Issue 9 , 2022
Abstract
Background: Previous studies have pointed to the major role of viruses in the pathogenesis of cancers, especially lymphoproliferative cancers.
Objectives: The current study investigated the relationship between recent Human Herpesvirus Type 6 (HHV6) infection and childhood leukemia-lymphoma syndrome. ...
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Background: Previous studies have pointed to the major role of viruses in the pathogenesis of cancers, especially lymphoproliferative cancers.
Objectives: The current study investigated the relationship between recent Human Herpesvirus Type 6 (HHV6) infection and childhood leukemia-lymphoma syndrome.
Methods: From January 2011 to December 2012, we entered every new case of acute lymphoblastic leukemia, non-Hodgkin lymphoma, acute myeloblastic leukemia, and Hodgkin lymphoma as the case group (n=48); moreover, 60 patients were randomly selected as controls from hospitalized children without infectious agents and myocarditis in the department of pediatric cardiology in Shiraz, Iran. Immunophenotyping of bone marrow or lymph node biopsy was performed for the case group. The DNA was extracted from all collected samples using a DNA extraction kit (Invitek Company, Germany), and a Real-time quantitative polymerase chain reaction (qPCR) for the U38 gene of HHV-6 was performed for the detection of the HHV-6 genome for both groups.
Results: In the case group, 48 patients with the age range of 0-18 years were assigned to four subgroups: 1- Acute Lymphoblastic Leukemia, 2- Acute Myeloblastic Leukemia, 3- Hodgkin Lymphoma, and 4- non-Hodgkin Lymphoma. In the case group, there were four positive HHV-6 PCR patients: One in Acute Lymphoblastic Leukemia, one in Non-Hodgkin Lymphoma, and two patients in the Hodgkin Lymphoma subgroup. None of the patients with T-cell leukemia-lymphoma had positive PCR. The frequency of HHV6 PCR positive was not significantly different between the case (8.3%) and control (1.6%) groups (P=0.169). No HHV-6 PCR positive was detected in T-cell leukemia/lymphoma patients.
Conclusion: As evidenced by the results of the present study, HHV-6 infection has no significant difference in children with T-Cell leukemia-lymphoma and healthy people.
Hassan Nourmohammadi; Sara Yousefzadeh Shoushtari; Lila Jouybari; Maryam Ghasemi; Abas Ghaysouri; Kambiz Keshavarz
Volume 23, Issue 7 , 2021
Abstract
Background: Breast cancer is the most common malignancy and a leading cause of death in women. Viruses are known to be the risk factors for breast cancer. The present study aimed to evaluate the association between human papillomavirus (HPV) and the development of breast cancer in Iranian women by a ...
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Background: Breast cancer is the most common malignancy and a leading cause of death in women. Viruses are known to be the risk factors for breast cancer. The present study aimed to evaluate the association between human papillomavirus (HPV) and the development of breast cancer in Iranian women by a systematic review and meta-analysis.
Methods: The international databases, including Web of Science, Embase, PubMed, Cochrane, and Scopus, were searched in this study. Furthermore, relevant studies published on the association between HPV and breast cancer were identified using the appropriate keywords. The data were analyzed in Stata software (version 14) using the random-effects model.
Results: In total, 18 studies were found eligible to be included in this study. The total sample size was determined at 2466 cases with the mean ages of 47.25 and 39.9 years for experimental and control groups. The overall findings showed a significant relationship between developing breast cancer and HPV infection. The results also revealed that the HPV infection increased the risk of breast cancer in women 5.02 fold more than those without HPV infection (95% CI: 3.46-7.29, I2=65.2%, P=0.003). In addition, the prevalence of HPV infection among women with breast cancer was estimated at 25.66% (95% CI: 17.34-34.95, I2=86%, P=0.000).
Conclusion: HPV infections, especially high-risk HPVs, are significantly frequent in breast cancer samples and should be considered an important risk factor for developing breast cancer.
